PTPN22 inhibition resets defective human central B cell tolerance
نویسندگان
چکیده
منابع مشابه
Defective B cell tolerance checkpoints in systemic lupus erythematosus
A cardinal feature of systemic lupus erythematosus (SLE) is the development of autoantibodies. The first autoantibodies described in patients with SLE were those specific for nuclei and DNA, but subsequent work has shown that individuals with this disease produce a panoply of different autoantibodies. Thus, one of the constant features of SLE is a profound breakdown in tolerance in the antibody...
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The CBA/N strain of mouse, derived in 1966 from the C B A / H strain (1), carries an X-linked mutation whose expression affects a number of B-cell functions. The B cells in adult CBA/N mice have many of the characteristics of those found in neonatal mice, including a higher density of surface IgM and a lower expression of B-cell differentiation markers, such as Ia, Mls, Lyb3, and Lyb5.1 (2-5). ...
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The CBA/N strain of mouse, derived in 1966 from the C B A / H strain (1), carries an X-linked mutation whose expression affects a number of B-cell functions. The B cells in adult CBA/N mice have many of the characteristics of those found in neonatal mice, including a higher density of surface IgM and a lower expression of B-cell differentiation markers, such as Ia, Mls, Lyb3, and Lyb5.1 (2-5). ...
متن کاملThe PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signaling involved in the regulation of central B cell tolerance. To assess whether this PTPN22 risk allele affects the removal of developing autoreactive B cells, we tested by ELISA ...
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ژورنال
عنوان ژورنال: Science Immunology
سال: 2016
ISSN: 2470-9468
DOI: 10.1126/sciimmunol.aaf7153